MutPred provides predictions of functional or deleterious amino acid substitutions, and was recently published in the journal Bioinformatics. This tool requires a protein sequence, a list of amino acid substitutions and an email address. Suggestions for effect on the molecular function are then provided. Please, see the about page for more information about the method and citing use of the method. This method was developed by Biao Li at Indiana University School of Informatics and Computing and was a joint project of the Mooney laboratory at the Buck Institute for Age Research and the Radivojac laboratory at Indiana University.
If you would like to run very large datasets (hundreds or thousands of substitutions), contact Dr. Predrag Radivojac.